FIBROMYALGIA NEWS
UPDATE Nov. 1, 2004
Xyrem (Sodium oxybate), a medicine currently improved for the sleep disorder, narcolepsy, was found to help fibromyalgia pain and fibromyalgia-related fatigue in two double blind studies published in the Journal of Rheumatology (1,2). A large double-blind study of Xyrem for fibromyalgia is currently in process.
Our office has recently joined the Xyrem double-blind study.
Participants must be non-pregnant, not nursing, 18 years of age or older, have a diagnosis of fibromyalgia and otherwise be in good health.
This 3 month, 7 visit study includes four overnight sleep studies. Qualified participants will receive study medication, study related physical exams and laboratory tests at no charge as well as reimbursement for time and travel expenses. The total possible compensation for a full participant would be $1,290.
The study requires that we taper patients off anti-depressant, anti-seizure and hypnotic class medicines. Therefore, patients entering the study should be at a mild enough stage for this to be practical. Over-the-counter pain relief medicines may be used.
If you are from New Jersey or New York and would like more information about the study, please call Wendy King, R.N., Ph.D, or Beverly Licata, R.N. at 973 218-9191.
Or contact Orphan Medical, Inc. Telephone: 1-800-888-8orphan or 952-513-6903 to find participating clinical trial sites.
Orphan Medical's Website: http://www.orphanmedical.com/
For Further Information on Fibromyalgia Treatment
For Further Information on Fibromyalgia Disability
UPDATE October 1, 2004
MEDICINES OPTIONS FOR FIBROMYALGIA PAIN
(Please feel free to share this with your physician.)
.
CLASS/medicine |
Evidence Level *
|
TRICYCLICS
amitryptiline/Elavil
Cyclobenzaprine/Flexeril |
A
A
|
SEROTONIN SUBTYPE 3 (5HT3)
ANTAGONIST
tropisetron**
odanseteron/ Zofran |
A
B |
NMDA ANTAGONIST
Ketamine I.V.
Dextromethorphan |
A
C
|
GROWTH HORMONE RELATED
GH injections
Pyridostigmine/Mestinon |
B
?
|
NOREPINEPHRINE/SEROTONIN
REUPTAKE INHIBITORS (NSRI)
duloxetine/Cymbalta
milnacipran**
Venflaxine/Effexor |
B
B
C |
ANTISEIZURE/GABA agonist
pregabalin/Lyrica*
Gabapentin/Neurontin
GHB/Zyrem (also known as sodium oxybate) |
B
C
B
|
OPIOID-RELATED
tramadol/Ultram
Narcotic Pain Medicines |
B
C
|
ANESTHETIC
lidocaine, I.V. |
B
|
SEROTONIN RE-UPTAKE INHIBITORS (SSRI) |
C |
NSAIDS and COX-2 INHIBITORS |
C |
DOPAMINE AGONIST
pramipexole/Mirapex
bupropion/Wellbutrin |
B
C
|
acetaminophen/Tylenol |
C |
MULTIPLE SCLEROSIS-RELATED
tizanidine/Zanaflex
baclofen |
C
C
|
* Evidence level: A=three or more positive double-blind controlled studies and no major negative trials. B=one or two positive double-blind controlled studies. C=Mixed results in double- blind studies or anecdotal support
** Not available in U.S.
For Further Information on Fibromyalgia Treatment
For Further Information on Fibromyalgia Disability
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